beta-Arrestin 1(Ser412) Antibody
- Size
- 0.1ml
- Catalog no.
- bs-3048R
- Price
- 281 EUR
Buy
Modification site(s)
Ser412
French translation
anticorps
Concentration
1ug per 1ul
Modification(s)
Phosphorylation
Cross reactivity
Human, Mouse, Rat
Category
Primary Antibodies
Clonality
Polyclonal antibody
Clone number
Polyclonal antibody
Tested Applications
WB, IHC-P, IF(IHC-P)
Target Antigen
beta-Arrestin 1Ser412
Long name
beta-Arrestin 1(Ser412) Antibody
Also known as
beta-Arrestin 1(Ser412) Antibody
Purification method
This antibody was purified via Protein A.
Recommended dilutions
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Specificity
This is a highly specific antibody against beta-Arrestin 1Ser412.
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source
KLH conjugated synthetic phosphopeptide derived from human beta-Arrestin 1 around the phosphorylation site of Ser412
Synonym names
beta Arrestin 1 phospho S412; p-beta Arrestin 1 phospho S412; ARB 1; ARB1; ARR 1; ARR1; ARRB 1; ARRB1; Arrestin beta 1.
Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Background of the target antigen
Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
