Smo agonist, SAG dihydrochloride for cell activation

Smo agonist, SAG dihydrochloride for cell activation
Size
5 mg
Catalog no.
2801-5
Price
751 EUR
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Is it cell-permeable?

Y

Is this a salt?

No

Peptide sequence

N/A

Supplied with

N/A

Tissue

cell

Storage condition

-20°C

Molecular weight

562.98

Shipping condition

Gel Pack

Maximum time for storage

36 months

CAS number

364590-63-6

Category

Biochemicals

Purification

≥98% by HPLC

Physical appearance

Light yellow solid

Molecular formula

C₂₈H₂₈ClN₃OS. 2HCl

Storage instructions

Protect from light and moisture

Reconstitute instructions

H2O (~ 25 mg/ml) DMSO (~ 10 mg/ml)

Additional description

For cells, cell lines and tissues in culture till half confluency.

Other name

N-Methyl-N′-(3-pyridinylbenzyl)-N′-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, dihydrochloride

Description

SAG hydrochloride is the water-soluble analog of SAG (Cat. No.1939). A cell-permeable Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low concentrations, but can inhibit Smo at very high concentrations.