Recombinant Human β-Arrestin 1/ARRB1 Protein(C-6His) 50µg

Recombinant Human β-Arrestin 1/ARRB1 Protein(C-6His) 50µg
Size
50µg
Catalog no.
PKSH033262-50µg
Price
438 EUR
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Activity

NA

Fusion tag

C-6His

Accession

P49407

AP Mol Mass

50 kDa

Expressed Host

E.coli

Mol Mass

48.1 kDa

Sequence

Met1-Arg418

Group

recombinants

Source

Recombinants or rec. proteins

Purity

>95% as determined by reducing SDS-PAGE.

Reconstitution

Please refer to it for detailed information.

Endotoxin

<1.0 EU per µg as determined by LAL test.

Synonym

Beta-Arrestin-1; Arrestin Beta-1; ARRB1; ARR1

Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability and Storage

Lyophilized protein should be stored at <-20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at <-20℃ for 3 months

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Background

β-Arrestin-1 (ARRB1) is a cytoplasmic protein that belongs to the arrestin family. ARRB1 is expressed at high levels in peripheral blood leukocytes and the central nervous system. ARRB1 regulates agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. ARRB1 acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. ARRB1 is believed to play a major role in regulating receptor-mediated immune functions. ARRB1 is involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6.